Multiple prebiotic metals mediate translation

Today, Mg(2+) is an essential cofactor with diverse structural and functional roles in life’s oldest macromolecular machine, the translation system. We tested whether ancient Earth conditions (low O(2), high Fe(2+), and high Mn(2+)) can revert the ribosome to a functional ancestral state. First, SHA...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Bray, Marcus S., Lenz, Timothy K., Haynes, Jay William, Bowman, Jessica C., Petrov, Anton S., Reddi, Amit R., Hud, Nicholas V., Williams, Loren Dean, Glass, Jennifer B.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2018
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6275528/
https://ncbi.nlm.nih.gov/pubmed/30413624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1803636115
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