Renal Cell Carcinoma (RCC) Tumors Display Large Expansion of Double Positive (DP) CD4+CD8+ T Cells With Expression of Exhaustion Markers

Checkpoint inhibitors target the inhibitory receptors expressed by tumor-infiltrating T cells in order to reinvigorate an anti-tumor immune response. Therefore, understanding T cell composition and phenotype in human tumors is crucial. We analyzed by flow cytometry tumor-infiltrating lymphocytes (TI...

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Dades bibliogràfiques
Publicat a:Front Immunol
Autors principals: Menard, Laurence C., Fischer, Paul, Kakrecha, Bijal, Linsley, Peter S., Wambre, Erik, Liu, Maochang C., Rust, Blake J., Lee, Deborah, Penhallow, Becky, Manjarrez Orduno, Nataly, Nadler, Steven G.
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2018
Matèries:
Immunology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6275222/
https://ncbi.nlm.nih.gov/pubmed/30534127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.02728
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