Inhibition of Microglia-Derived Oxidative Stress by Ciliary Neurotrophic Factor Protects Dopamine Neurons In Vivo from MPP(+) Neurotoxicity

We demonstrated that capsaicin (CAP), an agonist of transient receptor potential vanilloid subtype 1 (TRPV1), inhibits microglia activation and microglia-derived oxidative stress in the substantia nigra (SN) of MPP(+)-lesioned rat. However, the detailed mechanisms how microglia-derived oxidative str...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Baek, Jeong Yeob, Jeong, Jae Yeong, Kim, Kyoung In, Won, So-Yoon, Chung, Young Cheul, Nam, Jin Han, Cho, Eun Ju, Ahn, Tae-Beom, Bok, Eugene, Shin, Won-Ho, Jin, Byung Kwan
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6274815/
https://ncbi.nlm.nih.gov/pubmed/30423807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms19113543
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