In Vitro Reversible and Time-Dependent CYP450 Inhibition Profiles of Medicinal Herbal Plant Extracts Newbouldia laevis and Cassia abbreviata: Implications for Herb-Drug Interactions

This study evaluated the effects of Newbouldia laevis and Cassia abbreviata extracts on CYP450 enzyme activity. Recombinant CYP450 enzyme and fluorogenic substrates were used for evaluating inhibition, allowing the assessment of herb–drug interactions (HDI). Phytochemical fingerprinting was performe...

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Publicat a:Molecules
Autors principals: Thomford, Nicholas Ekow, Dzobo, Kevin, Chopera, Denis, Wonkam, Ambroise, Maroyi, Alfred, Blackhurst, Dee, Dandara, Collet
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6274561/
https://ncbi.nlm.nih.gov/pubmed/27399660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules21070891
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