Prenylated Chalcone 2 Acts as an Antimitotic Agent and Enhances the Chemosensitivity of Tumor Cells to Paclitaxel

We previously reported that prenylated chalcone 2 (PC2), the O-prenyl derivative (2) of 2′-hydroxy-3,4,4′,5,6′-pentamethoxychalcone (1), induced cytotoxicity of tumor cells via disruption of p53-MDM2 interaction. However, the cellular changes through which PC2 exerts its cytotoxic activity and its a...

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Udgivet i:Molecules
Main Authors: Fonseca, Joana, Marques, Sandra, Silva, Patrícia M. A., Brandão, Pedro, Cidade, Honorina, Pinto, Madalena M., Bousbaa, Hassan
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6274318/
https://ncbi.nlm.nih.gov/pubmed/27483224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules21080982
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