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Efficient Synthesis of Fully Substituted Pyrrolidine-Fused 3-Spirooxindoles via 1,3-Dipolar Cycloaddition of Aziridine and 3-Ylideneoxindole

Drug-like spirocyclic scaffolds have been prepared by fusing fully functionalized pyrrolidine with oxindoles in an approach based on 1,3-dipolar cycloaddition. Reaction between aziridine and 3-ylideneoxindole generated diverse spirooxindole-pyrrolidines in good yield (up to 95%) with high diastereos...

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Dades bibliogràfiques
Publicat a:Molecules
Autors principals: Ren, Wen, Zhao, Qian, Zheng, Chuan, Zhao, Qiong, Guo, Li, Huang, Wei
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6274301/
https://ncbi.nlm.nih.gov/pubmed/27563867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules21091113
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