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Design, Synthesis and Structure-Activity Relationships of Novel Diaryl Urea Derivatives as Potential EGFR Inhibitors

Two novel series of diaryl urea derivatives 5a–i and 13a–l were synthesized and evaluated for their cytotoxicity against H-460, HT-29, A549, and MDA-MB-231 cancer cell lines in vitro. Therein, 4-aminoquinazolinyl-diaryl urea derivatives 5a–i demonstrated significant activity, and seven of them are m...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Jiang, Nan, Bu, Yanxin, Wang, Yu, Nie, Minhua, Zhang, Dajun, Zhai, Xin
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6273962/
https://ncbi.nlm.nih.gov/pubmed/27869742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules21111572
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