LC-UV Determination of Baicalin in Rabbit Plasma and Tissues for Application in Pharmacokinetics and Tissue Distribution Studies of Baicalin after Intravenous Administration of Liposomal and Injectable Formulations

A simple and sensitive LC-UV method to investigate the pharmacokinetics and biodistribution pattern of baicalin in rabbits was established and validated. Baicalin and the internal standard, rutin, were extracted from biosamples using acetonitrile as protein precipitation after pretreated with ammoni...

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Pubblicato in:Molecules
Autori principali: Wei, Yumeng, Pi, Chao, Yang, Gang, Xiong, Xiaoming, Lan, Yongshu, Yang, Hongru, Zhou, Yang, Ye, Yun, Zou, Yonggen, Zheng, Wenwu, Zhao, Ling
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6273141/
https://ncbi.nlm.nih.gov/pubmed/27104507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules21040444
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