NO-Releasing Enmein-Type Diterpenoid Derivatives with Selective Antiproliferative Activity and Effects on Apoptosis-Related Proteins

A series of nine enmein-type ent-kaurane diterpenoid and furoxan-based nitric oxide (NO) donor hybrids (10a–i) were designed and synthesized from commercially available oridonin (1). These hybrids were evaluated for their antiproliferative activity against Bel-7402, K562, MGC-803, and CaEs-17 human...

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Pubblicato in:Molecules
Autori principali: Li, Dahong, Hu, Xu, Han, Tong, Liao, Jie, Xiao, Wei, Xu, Shengtao, Li, Zhanlin, Wang, Zhenzhong, Hua, Huiming, Xu, Jinyi
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6272893/
https://ncbi.nlm.nih.gov/pubmed/27617998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules21091193
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