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Enhanced Supersaturation and Oral Absorption of Sirolimus Using an Amorphous Solid Dispersion Based on Eudragit(®) E
The present study aimed to investigate the effect of Eudragit(®) E/HCl (E-SD) on the degradation of sirolimus in simulated gastric fluid (pH 1.2) and to develop a new oral formulation of sirolimus using E-SD solid dispersions to enhance oral bioavailability. Sirolimus-loaded solid dispersions were f...
Gardado en:
| Publicado en: | Molecules |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
MDPI
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6272523/ https://ncbi.nlm.nih.gov/pubmed/26020699 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules20069496 |
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