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Synthesis and Biological Evaluation of Novel Water-Soluble Poly-(ethylene glycol)-10-hydroxycamptothecin Conjugates

In order to improve the antitumor activity and water solubility of 10-hydroxycamptothecin (HCPT), a series of novel HCPT conjugates were designed and synthesized by conjugating polyethylene glycol (PEG) to the 10-hydroxyl group of HCPT via a valine spacer. The in vitro stability of these synthesized...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Guo, Na, Jiang, Du, Wang, Luyao, You, Xing, Teng, Yu-Ou, Yu, Peng
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6272474/
https://ncbi.nlm.nih.gov/pubmed/26007190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules20059393
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