A Facile Ionic Liquid Promoted Synthesis, Cholinesterase Inhibitory Activity and Molecular Modeling Study of Novel Highly Functionalized Spiropyrrolidines

A series of novel dimethoxyindanone embedded spiropyrrolidines were synthesized in ionic liquid, [bmim]Br and were evaluated for their inhibitory activities towards cholinesterases. Among the spiropyrrolidines, compound 4f exhibited the most potent activity with an IC(50) value of 1.57 µM against ac...

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Bibliografiska uppgifter
I publikationen:Molecules
Huvudupphovsmän: Almansour, Abdulrahman I., Suresh Kumar, Raju, Arumugam, Natarajan, Basiri, Alireza, Kia, Yalda, Ali, Mohamed Ashraf, Farooq, Mehvish, Murugaiyah, Vikneswaran
Materialtyp: Artigo
Språk:Inglês
Publicerad: MDPI 2015
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6272427/
https://ncbi.nlm.nih.gov/pubmed/25642838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules20022296
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