NBM-T-BBX-OS01, Semisynthesized from Osthole, Induced G1 Growth Arrest through HDAC6 Inhibition in Lung Cancer Cells

Disrupting lung tumor growth via histone deacetylases (HDACs) inhibition is a strategy for cancer therapy or prevention. Targeting HDAC6 may disturb the maturation of heat shock protein 90 (Hsp90) mediated cell cycle regulation. In this study, we demonstrated the effects of semisynthesized NBM-T-BBX...

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Veröffentlicht in:Molecules
Hauptverfasser: Pai, Jih-Tung, Hsu, Chia-Yun, Hua, Kuo-Tai, Yu, Sheng-Yung, Huang, Chung-Yang, Chen, Chia-Nan, Liao, Chiung-Ho, Weng, Meng-Shih
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6272357/
https://ncbi.nlm.nih.gov/pubmed/25946558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules20058000
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