Saikosaponin D Isolated from Bupleurum falcatum Inhibits Selectin-Mediated Cell Adhesion

Three saikosaponins were isolated from the MeOH extract of the roots of Bupleurum falcatum L.: saikosaponins B3 (1); B4 (2); and D (3). Of the three, compound 3 inhibited the interaction of selectins (E, L, and P) and THP-1 cells with IC(50) values of 1.8, 3.0 and 4.3 µM, respectively. Also, the agl...

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Detalles Bibliográficos
Publicado en:Molecules
Main Authors: Jang, Myoung-Jun, Kim, Ye Sol, Bae, Eun Young, Oh, Tae-Seok, Choi, Hwa-Jung, Lee, Jung-Hee, Oh, Hyun-Mee, Lee, Seung Woong
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2014
Assuntos:
Communication
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6271981/
https://ncbi.nlm.nih.gov/pubmed/25486247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules191220340
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