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Preparation of Rotenone Derivatives and in Vitro Analysis of Their Antimalarial, Antileishmanial and Selective Cytotoxic Activities

Six derivatives of the known biopesticide rotenone were prepared by several chemical transformations. Rotenone and its derivatives showed differential in vitro antiparasitic activity and selective cytotoxicity. In general, compounds were more active against Plasmodium falciparum than Leishmania pana...

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Publicat a:Molecules
Autors principals: Upegui, Yulieth, Gil, Juan F., Quiñones, Wiston, Torres, Fernando, Escobar, Gustavo, Robledo, Sara M., Echeverri, Fernando
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6271323/
https://ncbi.nlm.nih.gov/pubmed/25412039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules191118911
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