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DNA Condensation by Partially Acetylated Poly(amido amine) Dendrimers: Effects of Dendrimer Charge Density on Complex Formation

The ability of poly(amido amine) (or PAMAM) dendrimers to condense semiflexible dsDNA and penetrate cell membranes gives them great potential in gene therapy and drug delivery but their high positive surface charge makes them cytotoxic. Here, we describe the effects of partial neutralization by acet...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Molecules
Prif Awduron: Yu, Shi, Li, Ming-Hsin, Choi, Seok Ki, Baker, James R., Larson, Ronald G.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: MDPI 2013
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6271276/
https://ncbi.nlm.nih.gov/pubmed/24005965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules180910707
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