Synthesis and Biological Evaluation of Novel 10-Substituted-7-ethyl-10-hydroxycamptothecin (SN-38) Prodrugs

In an attempt to improve the antitumor activity and reduce the side effects of irinotecan (2), novel prodrugs of SN-38 (3) were prepared by conjugating amino acids or dipeptides to the 10-hydroxyl group of SN-38 via a carbamate linkage. The synthesized compounds completely generated SN-38 in pH 7.4...

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Bibliografiska uppgifter
I publikationen:Molecules
Huvudupphovsmän: Zhou, Mo, Liu, Meixia, He, Xinhua, Yu, Hong, Wu, Di, Yao, Yishan, Fan, Shiyong, Zhang, Ping, Shi, Weiguo, Zhong, Bohua
Materialtyp: Artigo
Språk:Inglês
Publicerad: MDPI 2014
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6270839/
https://ncbi.nlm.nih.gov/pubmed/25438082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules191219718
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