5-Episinuleptolide Acetate, a Norcembranoidal Diterpene from the Formosan Soft Coral Sinularia sp., Induces Leukemia Cell Apoptosis through Hsp90 Inhibition

5-Episinuleptolide acetate (5EPA), a cytotoxic norcembranoidal diterpene recently identified from the Formosan soft coral Sinularia sp., exhibited potent activity against the K562, Molt 4 and HL 60 cancer cell lines. The antiproliferative assay, as well as the annexin V-FITC/propidium iodide (PI) ap...

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Bibliographic Details
Published in:Molecules
Main Authors: Huang, Kao-Jean, Chen, Yu-Cheng, El-Shazly, Mohamed, Du, Ying-Chi, Su, Jui-Hsin, Tsao, Chia-Wei, Yen, Wei-Hsuan, Chang, Wen-Been, Su, Yin-Di, Yeh, Yao-Tsung, Lu, Mei-Chin
Format: Artigo
Language:Inglês
Published: MDPI 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6270000/
https://ncbi.nlm.nih.gov/pubmed/23459302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules18032924
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