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Synthesis and SAR Studies of Praziquantel Derivatives with Activity against Schistosoma japonicum

The synthesis and structure-activity relationship (SAR) studies of praziquantel derivatives with activity against adult Schistosoma japonicum are described. Several of them showed better worm killing activity than praziquantel and could serve as leads for further optimization.

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Foilsithe in:Molecules
Main Authors: Wang, Wen-Long, Song, Li-Jun, Chen, Xia, Yin, Xu-Ren, Fan, Wen-Hua, Wang, Gu-Ping, Yu, Chuan-Xin, Feng, Bainian
Formáid: Artigo
Teanga:Inglês
Foilsithe: MDPI 2013
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6269691/
https://ncbi.nlm.nih.gov/pubmed/23912271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules18089163
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