High resolution X-ray and NMR structural study of human T-cell immunoglobulin and mucin domain containing protein-3

T-cell immunoglobulin and mucin domain containing protein-3 (TIM-3) is an important immune regulator. Here, we describe a novel high resolution (1.7 Å) crystal structure of the human (h)TIM-3 N-terminal variable immunoglobulin (IgV) domain with bound calcium (Ca(++)) that was confirmed by nuclear ma...

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Pubblicato in:Sci Rep
Autori principali: Gandhi, Amit K., Kim, Walter M., Sun, Zhen-Yu J., Huang, Yu-Hwa, Bonsor, Daniel A., Sundberg, Eric J., Kondo, Yasuyuki, Wagner, Gerhard, Kuchroo, Vijay K., Petsko, Gregory, Blumberg, Richard S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6269442/
https://ncbi.nlm.nih.gov/pubmed/30504845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-35754-0
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