Diagnostics for Pleiotropy in Mendelian Randomization Studies: Global and Individual Tests for Direct Effects

Diagnosing pleiotropy is critical for assessing the validity of Mendelian randomization (MR) analyses. The popular MR-Egger method evaluates whether there is evidence of bias-generating pleiotropy among a set of candidate genetic instrumental variables. In this article, we propose a statistical meth...

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Detalles Bibliográficos
Publicado en:Am J Epidemiol
Main Authors: Dai, James Y, Peters, Ulrike, Wang, Xiaoyu, Kocarnik, Jonathan, Chang-Claude, Jenny, Slattery, Martha L, Chan, Andrew, Lemire, Mathieu, Berndt, Sonja I, Casey, Graham, Song, Mingyang, Jenkins, Mark A, Brenner, Hermann, Thrift, Aaron P, White, Emily, Hsu, Li
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2018
Assuntos:
Practice of Epidemiology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6269243/
https://ncbi.nlm.nih.gov/pubmed/30188971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/aje/kwy177
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