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Synthesis, DNA-Binding and Antiproliferative Properties of Acridine and 5-Methylacridine Derivatives

Several acridine derivatives were synthesized and their anti-proliferative activity was determined. The most active molecules were derivatives of 5-methylacridine-4-carboxylic acid. The DNA binding properties of the synthesized acridines were analyzed by competitive dialysis and compared with the an...

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Vydáno v:Molecules
Hlavní autoři: Ferreira, Rubén, Aviñó, Anna, Mazzini, Stefania, Eritja, Ramon
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6269017/
https://ncbi.nlm.nih.gov/pubmed/22683895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules17067067
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