Effects of Ser47-Point Mutation on Conformation Structure and Allergenicity of the Allergen of Der p 2, a Major House Dust Mite Allergen

PURPOSE: Hypoallergenic recombinant Der p 2 has been produced by various genetic manipulations, but mutation of a naturally polymorphic amino acid residue known to affect IgE binding has not been studied. This study aimed to determine the effect of a point mutation (S47W) of residue 47 of Der p 2 on...

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Pubblicato in:Allergy Asthma Immunol Res
Autori principali: Kulwanich, Bhakkawarat, Thanyaratsrisakul, Sasipa, Jirapongsananuruk, Orathai, Hales, Belinda J., Thomas, Wayne R., Piboonpocanun, Surapon
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Disease 2018
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6267192/
https://ncbi.nlm.nih.gov/pubmed/30479083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4168/aair.2019.11.1.129
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