Inadequate ubiquitination-proteasome coupling contributes to myocardial ischemia-reperfusion injury

The ubiquitin-proteasome system (UPS) degrades a protein molecule via 2 main steps: ubiquitination and proteasomal degradation. Extraproteasomal ubiquitin receptors are thought to couple the 2 steps, but this proposition has not been tested in vivo with vertebrates. More importantly, impaired UPS pe...

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Publicado en:J Clin Invest
Autores principales: Hu, Chengjun, Tian, Yihao, Xu, Hongxin, Pan, Bo, Terpstra, Erin M., Wu, Penglong, Wang, Hongmin, Li, Faqian, Liu, Jinbao, Wang, Xuejun
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2018
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6264645/
https://ncbi.nlm.nih.gov/pubmed/30204128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI98287
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