PLK1 stabilizes a MYC-dependent kinase network in aggressive B cell lymphomas

Concordant activation of MYC and BCL-2 oncoproteins in double-hit lymphoma (DHL) results in aggressive disease that is refractory to treatment. By integrating activity-based proteomic profiling and drug screens, polo-like kinase-1 (PLK1) was identified as an essential regulator of the MYC-dependent...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Ren, Yuan, Bi, Chengfeng, Zhao, Xiaohong, Lwin, Tint, Wang, Cheng, Yuan, Ji, Silva, Ariosto S., Shah, Bijal D., Fang, Bin, Li, Tao, Koomen, John M., Jiang, Huijuan, Chavez, Julio C., Pham, Lan V., Sudalagunta, Praneeth R., Wan, Lixin, Wang, Xuefeng, Dalton, William S., Moscinski, Lynn C., Shain, Kenneth H., Vose, Julie, Cleveland, John L., Sotomayor, Eduardo M., Fu, Kai, Tao, Jianguo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6264635/
https://ncbi.nlm.nih.gov/pubmed/30260324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI122533
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