Long noncoding RNA Bmncr regulates mesenchymal stem cell fate during skeletal aging

Bone marrow mesenchymal stem cells (BMSCs) exhibit an age-related lineage switch between osteogenic and adipogenic fates, which contributes to bone loss and adiposity. Here we identified a long noncoding RNA, Bmncr, which regulated the fate of BMSCs during aging. Mice depleted of Bmncr (Bmncr-KO) sh...

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Bibliographic Details
Published in:J Clin Invest
Main Authors: Li, Chang-Jun, Xiao, Ye, Yang, Mi, Su, Tian, Sun, Xi, Guo, Qi, Huang, Yan, Luo, Xiang-Hang
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2018
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6264619/
https://ncbi.nlm.nih.gov/pubmed/30352426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI99044
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