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Positive Modulation of mGluR5 Attenuates Seizures and Reduces TNF-α(+) Macrophages and Microglia in the Brain in a Murine Model of Virus-Induced Temporal Lobe Epilepsy

Viral encephalitis markedly increases the risk for the development of epilepsy. The Theiler’s murine encephalomyelitis virus (TMEV)-induced model of seizures/epilepsy is a murine model of both viral-induced seizures/epilepsy and human Temporal Lobe Epilepsy. The inflammatory cytokines interleukin (I...

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Detalhes bibliográficos
Publicado no:Exp Neurol
Main Authors: Hanak, Tyler J., Libbey, Jane E., Doty, Daniel J., Sim, Jordan T., DePaula-Silva, Ana Beatriz, Fujinami, Robert S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6263825/
https://ncbi.nlm.nih.gov/pubmed/30316834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2018.10.006
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