Population Pharmacokinetics and Exploratory Exposure‐Response Relationships of Diazepam in Children Treated for Status Epilepticus

Diazepam is labeled for status epilepticus (SE) in children, but there are limited data characterizing its disposition in pediatric patients. We developed a population pharmacokinetic (PK) model of i.v. diazepam in children with SE. We evaluated relationships between PK parameters and both safety an...

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Detalhes bibliográficos
Publicado no:CPT Pharmacometrics Syst Pharmacol
Main Authors: Ku, Lawrence C., Hornik, Christoph P., Beechinor, Ryan J., Chamberlain, James M., Guptill, Jeffrey T., Harper, Barrie, Capparelli, Edmund V., Martz, Karen, Anand, Ravinder, Cohen‐Wolkowiez, Michael, Gonzalez, Daniel, Furda, Gary, Benjamin, Danny, Kearns, Gregory L., Paul, Ian M., Sullivan, Jan, Wade, Kelly, Siegel, David, Taylor‐Zapata, Perdita, Zajicek, Anne, Ren, Zhaoxia, Tsilou, Ekaterini, Pagan, Alice, Simone, Gina, Ku, Lawrence, Mills, Mary, Watt, Kevin
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6263663/
https://ncbi.nlm.nih.gov/pubmed/30267478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12349
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