Receiver Operating Characteristic Analysis and Clinical Trial Simulation to Inform Dose Titration Decisions

Optimal dose selection in clinical trials is problematic when efficacious and toxic concentrations are close. A novel quantitative approach follows for optimizing dose titration in clinical trials. A system of pharmacokinetics (PK), pharmacodynamics, efficacy, and toxicity was simulated for scenario...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:CPT Pharmacometrics Syst Pharmacol
Autors principals: Clements, John David, Perez Ruixo, Juan Jose, Gibbs, John P., Doshi, Sameer, Perez Ruixo, Carlos, Melhem, Murad
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2018
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6263661/
https://ncbi.nlm.nih.gov/pubmed/30246497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12354
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars