Mangiferin, an Anti-HIV-1 Agent Targeting Protease and Effective against Resistant Strains

The anti-HIV-1 activity of mangiferin was evaluated. Mangiferin can inhibit HIV-1(ⅢB) induced syncytium formation at non-cytotoxic concentrations, with a 50% effective concentration (EC(50)) at 16.90 μM and a therapeutic index (TI) above 140. Mangiferin also showed good activities in other laborator...

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Veröffentlicht in:Molecules
Hauptverfasser: Wang, Rui-Rui, Gao, Yue-Dong, Ma, Chun-Hui, Zhang, Xing-Jie, Huang, Cheng-Gang, Huang, Jing-Fei, Zheng, Yong-Tang
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6263262/
https://ncbi.nlm.nih.gov/pubmed/21610656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules16054264
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