Mechanisms of TQ-6, a Novel Ruthenium-Derivative Compound, against Lipopolysaccharide-Induced In Vitro Macrophage Activation and Liver Injury in Experimental Mice: The Crucial Role of p38 MAPK and NF-κB Signaling

Several studies have reported that metal complexes exhibit anti-inflammatory activities; however, the molecular mechanism is not well understood. In this study, we used a potent ruthenium (II)-derived compound, [Ru(η6-cymene)2-(1H-benzoimidazol-2-yl)-quinoline Cl]BF4 (TQ-6), to investigate the molec...

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Vydáno v:Cells
Hlavní autoři: Hsia, Chih-Hsuan, Velusamy, Marappan, Jayakumar, Thanasekaran, Chen, Yen-Jen, Hsia, Chih-Wei, Tsai, Jie-Heng, Teng, Ruei-Dun, Sheu, Joen-Rong
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6262332/
https://ncbi.nlm.nih.gov/pubmed/30463239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells7110217
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