Partial loss of psychiatric risk gene miR-137 in mice causes repetitive behavior and impairs sociability and learning via increased Pde10a

Genetic analyses have linked MicroRNA-137 (MIR137) to neuropsychiatric disorders, including schizophrenia and autism spectrum disorder (ASD). MiR-137 plays important roles in neurogenesis and neuronal maturation, but the impact of miR-137 loss of function in vivo remains unclear. Here we show the co...

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Pubblicato in:Nat Neurosci
Autori principali: Cheng, Ying, Wang, Zhi-Meng, Tan, Weiqi, Wang, Xiaona, Li, Yujing, Bai, Bing, Li, Yuxin, Zhang, Shuang-Feng, Yan, Hai-Liang, Chen, Zuo-Lun, Liu, Chang-Mei, Mi, Ting-Wei, Xia, Shuting, Zhou, Zikai, Liu, An, Tang, Gang-Bin, Liu, Cong, Dai, Zhi-Jie, Wang, Ying-Ying, Wang, Hong, Wang, Xusheng, Kang, Yunhee, Lin, Li, Chen, Zhenping, Xie, Nina, Sun, Qinmiao, Xie, Wei, Peng, Junmin, Chen, Dahua, Teng, Zhao-Qian, Jin, Peng
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6261680/
https://ncbi.nlm.nih.gov/pubmed/30397325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41593-018-0261-7
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