Deficiency of the pattern-recognition receptor CD14 protects against joint pathology and functional decline in a murine model of osteoarthritis

OBJECTIVE: CD14 is a monocyte/macrophage pattern-recognition receptor that modulates innate inflammatory signaling. Soluble CD14 levels in knee OA synovial fluids are associated with symptoms and progression of disease. Here we investigate the role of this receptor in development of OA using a murin...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:PLoS One
Egile Nagusiak: Sambamurthy, Nisha, Zhou, Cheng, Nguyen, Vu, Smalley, Ryan, Hankenson, Kurt D., Dodge, George R., Scanzello, Carla R.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2018
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6261538/
https://ncbi.nlm.nih.gov/pubmed/30485272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0206217
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