Cerebrospinal fluid neurogranin/β-site APP-cleaving enzyme 1 predicts cognitive decline in preclinical Alzheimer's disease

INTRODUCTION: The cerebrospinal fluid neurogranin (Ng)/β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) ratio may reflect synaptic affection resulting from reduced beta-amyloid (Aβ) clearance. We hypothesize that increased Ng/BACE1 ratio predicts the earliest cognitive decline in Alzheimer...

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Detalhes bibliográficos
Publicado no:Alzheimers Dement (N Y)
Main Authors: Kirsebom, Bjørn-Eivind, Nordengen, Kaja, Selnes, Per, Waterloo, Knut, Torsetnes, Silje Bøen, Gísladóttir, Berglind, Brix, Britta, Vanmechelen, Eugeen, Bråthen, Geir, Hessen, Erik, Aarsland, Dag, Fladby, Tormod
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6260221/
https://ncbi.nlm.nih.gov/pubmed/30519627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.trci.2018.10.003
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