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Synthesis, Characterization and Biological Evaluation of Succinate Prodrugs of Curcuminoids for Colon Cancer Treatment

A novel series of succinyl derivatives of three curcuminoids were synthesized as potential prodrugs. Symmetrical (curcumin and bisdesmethoxycurcumin) and unsymmetrical (desmethoxycurcumin) curcuminoids were prepared through aldol condensation of 2,4-pentanedione with different benzaldehydes. Esterif...

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Bibliografische gegevens
Gepubliceerd in:Molecules
Hoofdauteurs: Wichitnithad, Wisut, Nimmannit, Ubonthip, Wacharasindhu, Sumrit, Rojsitthisak, Pornchai
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI 2011
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6259653/
https://ncbi.nlm.nih.gov/pubmed/21343891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules16021888
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