Direct Cardiac Actions of Sodium Glucose Cotransporter 2 Inhibitors Target Pathogenic Mechanisms Underlying Heart Failure in Diabetic Patients

Sodium glucose cotransporter 2 inhibitors (SGLT2i) are the first antidiabetic compounds that effectively reduce heart failure hospitalization and cardiovascular death in type 2 diabetics. Being explicitly designed to inhibit SGLT2 in the kidney, SGLT2i have lately been investigated for their off-tar...

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Dettagli Bibliografici
Pubblicato in:Front Physiol
Autori principali: Uthman, Laween, Baartscheer, Antonius, Schumacher, Cees A., Fiolet, Jan W. T., Kuschma, Marius C., Hollmann, Markus W., Coronel, Ruben, Weber, Nina C., Zuurbier, Coert J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2018
Soggetti:
Physiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6259641/
https://ncbi.nlm.nih.gov/pubmed/30519189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2018.01575
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