Salinomycin Inhibits Influenza Virus Infection by Disrupting Endosomal Acidification and Viral Matrix Protein 2 Function

Screening of chemical libraries with 2,000 synthetic compounds identified salinomycin as a hit against influenza A and B viruses, with 50% effective concentrations ranging from 0.4 to 4.3 μM in cells. This compound is a carboxylic polyether ionophore that exchanges monovalent ions for protons across...

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Detalles Bibliográficos
Publicado en:J Virol
Main Authors: Jang, Yejin, Shin, Jin Soo, Yoon, Yi-Seul, Go, Yun Young, Lee, Hye Won, Kwon, Oh Seung, Park, Sehee, Park, Man-Seong, Kim, Meehyein
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2018
Assuntos:
Vaccines and Antiviral Agents
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6258947/
https://ncbi.nlm.nih.gov/pubmed/30282713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01441-18
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