Alpha 1 Antitrypsin Gene Therapy Extends the Lifespan of Lupus-Prone Mice

Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease characterized by high levels of pathogenic autoantibodies and tissue damage. Multiple studies showed that dendritic cell (DC) activation plays a critical role in SLE pathogenesis. Human alpha 1 antitrypsin (hAAT) is a serine pr...

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Pubblicato in:Mol Ther Methods Clin Dev
Autori principali: Elshikha, Ahmed Samir, Yuan, Ye, Lu, Yuanqing, Chen, Mong-Jen, Abboud, Georges, Akbar, Mohammad Ahsanul, Plate, Henrike, Wolney, Hedwig, Hoffmann, Tanja, Tagari, Eleni, Zeumer, Leilani, Morel, Laurence, Song, Sihong
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Gene & Cell Therapy 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6258868/
https://ncbi.nlm.nih.gov/pubmed/30547047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2018.10.007
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