The in vivo and in vitro roles of Trypanosoma cruzi Rad51 in the repair of DNA double strand breaks and oxidative lesions

In Trypanosoma cruzi, the etiologic agent of Chagas disease, Rad51 (TcRad51) is a central enzyme for homologous recombination. Here we describe the different roles of TcRad51 in DNA repair. Epimastigotes of T. cruzi overexpressing TcRAD51 presented abundant TcRad51-labeled foci before gamma irradiat...

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Gepubliceerd in:PLoS Negl Trop Dis
Hoofdauteurs: Gomes Passos Silva, Danielle, da Silva Santos, Selma, Nardelli, Sheila C., Mendes, Isabela Cecília, Freire, Anna Cláudia Guimarães, Repolês, Bruno Marçal, Resende, Bruno Carvalho, Costa-Silva, Héllida Marina, da Silva, Verônica Santana, de Oliveira, Karla Andrade, Oliveira, Camila Franco Batista, Vilela, Liza Figueiredo Felicori, Nagem, Ronaldo Alves Pinto, Franco, Glória Regina, Macedo, Andrea Mara, Pena, Sergio Danilo Junho, Tahara, Erich Birelli, Sales Junior, Policarpo Ademar, Moreira, Douglas Souza, Teixeira, Santuza Maria Ribeiro, McCulloch, Richard, Virgilio, Stela, Tosi, Luiz Ricardo Orsini, Schenkman, Sergio, Andrade, Luciana Oliveira, Murta, Silvane Maria Fonseca, Machado, Carlos Renato
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2018
Onderwerpen:
Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6258567/
https://ncbi.nlm.nih.gov/pubmed/30422982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0006875
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