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Trichlorination of a Teicoplanin-Type Glycopeptide Antibiotic by the Halogenase StaI Evades Resistance

Glycopeptide antibiotics (GPAs) include clinically important drugs used for the treatment of infections caused by Gram-positive pathogens. These antibiotics are specialized metabolites produced by several genera of actinomycete bacteria. While many GPAs are highly chemically modified, A47934 is a re...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Yim, Grace, Wang, Wenliang, Pawlowski, Andrew C., Wright, Gerard D.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6256792/
https://ncbi.nlm.nih.gov/pubmed/30275088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01540-18
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