Pse-T2, an Antimicrobial Peptide with High-Level, Broad-Spectrum Antimicrobial Potency and Skin Biocompatibility against Multidrug-Resistant Pseudomonas aeruginosa Infection

Pseudin-2, isolated from the frog Pseudis paradoxa, exhibits potent antibacterial activity but also cytotoxicity. In an effort to develop clinically applicable antimicrobial peptides (AMPs), we designed pseudin-2 analogs with Lys substitutions, resulting in elevated amphipathic α-helical structure a...

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Библиографические подробности
Опубликовано в: :Antimicrob Agents Chemother
Главные авторы: Kang, Hee Kyoung, Seo, Chang Ho, Luchian, Tudor, Park, Yoonkyung
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2018
Предметы:
Experimental Therapeutics
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6256760/
https://ncbi.nlm.nih.gov/pubmed/30323036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01493-18
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