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Synthesis, characterization and biological activity of organometallic derivatives of the antimalarial drug mefloquine as new antischistosomal drug candidates

We present the design, synthesis, characterization and biological evaluation of new ferrocenyl and ruthenocenyl derivatives of the organic antimalarial mefloquine, a drug also known for its antischistosomal activity. The two metallocenyl derivatives prepared (3 and 4) demonstrated comparable activit...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Medchemcomm
Prif Awduron: d'Orchymont, Faustine, Hess, Jeannine, Panic, Gordana, Jakubaszek, Marta, Gemperle, Lea, Keiser, Jennifer, Gasser, Gilles
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Royal Society of Chemistry 2018
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6256353/
https://ncbi.nlm.nih.gov/pubmed/30568758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8md00396c
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