CYP3A4‐mediated effects of rifampicin on the pharmacokinetics of vilaprisan and its UGT1A1‐mediated effects on bilirubin glucuronidation in humans

AIMS: The primary aim of the present study was to quantify the effects of rifampicin, a strong cytochrome P450 (CYP) 3A4 inducer, on the pharmacokinetics of the new selective progesterone receptor modulator, vilaprisan. In addition, the effects of rifampicin on the glucuronidation of bilirubin, an e...

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Detalhes bibliográficos
Publicado no:Br J Clin Pharmacol
Main Authors: Chattopadhyay, Niladri, Kanacher, Tobias, Casjens, Manuela, Frechen, Sebastian, Ligges, Sandra, Zimmermann, Torsten, Rottmann, Antje, Ploeger, Bart, Höchel, Joachim, Schultze‐Mosgau, Marcus‐Hillert
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6256003/
https://ncbi.nlm.nih.gov/pubmed/30171692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13750
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