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RANKL signaling in bone marrow mesenchymal stem cells negatively regulates osteoblastic bone formation

RANKL signaling is essential for osteoclastogenesis. Its role in osteoblastic differentiation and bone formation is unknown. Here we demonstrate that RANK is expressed at an early stage of bone marrow mesenchymal stem cells (BMSCs) during osteogenic differentiation in both mice and human and decreas...

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Detalhes bibliográficos
Publicado no:Bone Res
Main Authors: Chen, Xiao, Zhi, Xin, Wang, Jun, Su, Jiacan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6255918/
https://ncbi.nlm.nih.gov/pubmed/30510839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41413-018-0035-6
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