Structural basis for activation of plasma-membrane Ca(2+)-ATPase by calmodulin

Plasma-membrane Ca(2+)-ATPases expel Ca(2+) from the cytoplasm and are key regulators of Ca(2+) homeostasis in eukaryotes. They are autoinhibited under low Ca(2+) concentrations. Calmodulin (CaM)-binding to a unique regulatory domain releases the autoinhibition and activates the pump. However, the s...

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Publicat a:Commun Biol
Autors principals: Nitsche, Julius, Josts, Inokentijs, Heidemann, Johannes, Mertens, Haydyn D., Maric, Selma, Moulin, Martine, Haertlein, Michael, Busch, Sebastian, Forsyth, V. Trevor, Svergun, Dmitri I., Uetrecht, Charlotte, Tidow, Henning
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6255812/
https://ncbi.nlm.nih.gov/pubmed/30511020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-018-0203-7
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