A biophysical study on the mechanism of interactions of DOX or PTX with α-lactalbumin as a delivery carrier

Doxorubicin and paclitaxel, two hydrophobic chemotherapeutic agents, are used in cancer therapies. Presence of hydrophobic patches and a flexible fold could probably make α-Lactalbumin a suitable carrier for hydrophobic drugs. In the present study, a variety of thermodynamic, spectroscopic, computat...

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Publicado no:Sci Rep
Main Authors: Delavari, Behdad, Mamashli, Fatemeh, Bigdeli, Bahareh, Poursoleiman, Atefeh, Karami, Leila, Zolmajd-Haghighi, Zahra, Ghasemi, Atiyeh, Samaei-Daryan, Samaneh, Hosseini, Morteza, Haertlé, Thomas, Muronetz, Vladimir I., Halskau, Øyvind, Moosavi-Movahedi, Ali Akbar, Goliaei, Bahram, Rezayan, Ali Hossein, Saboury, Ali Akbar
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6255783/
https://ncbi.nlm.nih.gov/pubmed/30478403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-35559-1
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