Three-dimensional in vitro modeling of malignant bone disease recapitulates experimentally accessible mechanisms of osteoinhibition

Malignant bone disease (MBD) occurs when tumors establish in bone, causing catastrophic tissue damage as a result of accelerated bone destruction and inhibition of repair. The resultant so-called osteolytic lesions (OL) take the form of tumor-filled cavities in bone that cause pain, fractures, and a...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: McNeill, Eoin P., Reese, Robert W., Tondon, Abishek, Clough, Bret H., Pan, Simin, Froese, Jeremiah, Palmer, Daniel, Krause, Ulf, Loeb, David M., Kaunas, Roland, Gregory, Carl A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6255770/
https://ncbi.nlm.nih.gov/pubmed/30478297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-1203-8
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