Synthesis of N-Substituted 5-Iodouracils as Antimicrobial and Anticancer Agents

This study reports the synthesis of some substituted 5-iodouracils and their bioactivities. Alkylation of 5-iodouracils gave predominately N1-substituted-(R)-5-iodouracil compounds 7a-d (R = n-C(4)H(9), s-C(4)H(9), CH(2)C(6)H(11), CH(2)C(6)H(5)) together with N1,N3-disubstituted (R) analogs 8a-b (R...

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Publicado no:Molecules
Main Authors: Prachayasittikul, Supaluk, Sornsongkhram, Nirun, Pingaew, Ratchanok, Worachartcheewan, Apilak, Ruchirawat, Somsak, Prachayasittikul, Virapong
Formato: Artigo
Idioma:Inglês
Publicado em: Molecular Diversity Preservation International 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6255094/
https://ncbi.nlm.nih.gov/pubmed/19701123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules14082768
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