Serum starvation raises turnover of phosphorylated p62/SQSTM1 (Serine 349), reveals expression of proteasome and N-glycanase1 interactive protein RAD23B and sensitizes human synovial fibroblasts to BAY 11-7085-induced cell death

Phosphorylation of p62/SQSTM1 (p62) on Serine 349 (P-Ser349 p62) as well as proteasome dysfunction have been shown to activate the cell protective Keap1/Nrf2 pathway. We showed previously that BAY 11-7085-induced human synovial fibroblast cell death includes autophagy and p62 downregulation. In this...

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Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: Relic, Biserka, Charlier, Edith, Deroyer, Celine, Malaise, Olivier, Crine, Yannick, Neuville, Sophie, Gillet, Philippe, de Seny, Dominique, Malaise, Michel G.
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2018
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6254681/
https://ncbi.nlm.nih.gov/pubmed/30533198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.26295
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