1417. Evaluating the Dissonance Between C(max) and AUC with Clinically Utilized Aminoglycoside (AG) Dosing Regimens: Use of Tobramycin (TOB) Against Pseudomonas aeruginosa (PA) as a Case Study

BACKGROUND: Current dogma suggests optimizing AG doses based on peak concentration (C(max)), without consideration of daily drug exposure (AUC(24)). The correlation between attainment of the TOB pharmacokinetic-pharmacodynamic (PK-PD) targets, C(max):MIC and AUC(24):MIC ratio was explored using a TO...

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Vydáno v:Open Forum Infect Dis
Hlavní autoři: Onufrak, Nikolas J, Bhavnani, Sujata M, Pogue, Jason M, Rubino, Christopher M
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6253600/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ofid/ofy210.1248
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